Mining the equine gut metagenome: poorly-characterized taxa associated with cardiovascular fitness in endurance athletes.

ABSTRACT: Emerging evidence indicates that the gut microbiome contributes to endurance exercise performance. Still, the extent of its functional and metabolic potential remains unknown. Using elite endurance horses as a model system for exercise responsiveness, we built an integrated horse gut gene catalog comprising ~25 million unique genes and 372 metagenome-assembled genomes. This catalog represents 4179 genera spanning 95 phyla and functional capacities primed to exploit energy from dietary, microbial, and host resources. The holo-omics approach shows that gut microbiomes enriched in Lachnospiraceae taxa are negatively associated with cardiovascular capacity. Conversely, more complex and functionally diverse microbiomes are associated with higher glucose concentrations and reduced accumulation o

SUBMITTER: Mach N 

PROVIDER: S-EPMC9529974 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature