Glucose-driven TOR-FIE-PRC2 signalling controls plant development.

ABSTRACT: Nutrients and energy have emerged as central modulators of developmental programmes in plants and animals^1-3. The evolutionarily conserved target of rapamycin (TOR) kinase is a master integrator of nutrient and energy signalling that controls growth. Despite its key regulatory roles in translation, proliferation, metabolism and autophagy^2-5, little is known about how TOR shapes developmental transitions and differentiation. Here we show that glucose-activated TOR kinase controls genome-wide histone H3 trimethylation at K27 (H3K27me3) in Arabidopsis thaliana, which regulates cell fate and development^6-10. We identify FERTILIZATION-INDEPENDENT ENDOSPERM (FIE), an indispensable component of Polycomb repressive complex 2 (PRC2), which catalyses H3K27me3 (refs. 

SUBMITTER: Ye R 

PROVIDER: S-EPMC9530021 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature