Coronary artery disease risk factors affected by RNA modification-related genetic variants.

ABSTRACT:

Background

Single nucleotide polymorphisms that affect RNA modification (RNAm-SNPs) may have functional roles in coronary artery disease (CAD). The aim of this study was to identify RNAm-SNPs in CAD susceptibility loci and highlight potential risk factors.

Methods

CAD-associated RNAm-SNPs were identified in the CARDIoGRAMplusC4D and UK Biobank genome-wide association studies. Gene expression and circulating protein levels affected by the RNAm-SNPs were identified by QTL analyses. Cell experiments and Mendelian randomization (MR) methods were applied to test whether the gene expression levels were associated with CAD.

Results

We identified 81 RNAm-SNPs that were associated with CAD or acute myocardial infarction (AMI), including m⁶A-, m¹A-, m

SUBMITTER: Li R 

PROVIDER: S-EPMC9530202 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature