First report of structural characteristics and polymorphisms of the prion protein gene in raccoon dogs: The possibility of prion disease-resistance.

ABSTRACT: Prion diseases are fatal degenerative encephalopathies caused by misfolded prion protein (PrP^Sc) converted from normal prion protein (PrP^C). Previous studies have reported that genetic polymorphisms of the prion protein gene (PRNP) play a critical role in susceptibility to prion diseases. In addition, prion disease-resistant animals showed unique structural features of prion protein (PrP) related to species-specific amino acids. However, investigations of genetic polymorphisms of the PRNP gene and structural characteristics of PrP have not been performed in raccoon dogs thus far. We investigated genetic polymorphisms of PRNP in 87 raccoon dogs using amplicon sequencing and analyzed the genotype, allele, haplotype frequencies, and linkage disequili

SUBMITTER: Jo WS 

PROVIDER: S-EPMC9530392 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature