Symptom-based case definitions for COVID-19: Time and geographical variations for detection at hospital admission among 260,000 patients.

ABSTRACT:

Introduction

Case definitions are used to guide clinical practice, surveillance and research protocols. However, how they identify COVID-19-hospitalised patients is not fully understood. We analysed the proportion of hospitalised patients with laboratory-confirmed COVID-19, in the ISARIC prospective cohort study database, meeting widely used case definitions.

Methods

Patients were assessed using the Centers for Disease Control (CDC), European Centre for Disease Prevention and Control (ECDC), World Health Organization (WHO) and UK Health Security Agency (UKHSA) case definitions by age, region and time. Case fatality ratios (CFRs) and symptoms of those who did and who did not meet the case definitions were evaluated. Patients with incomplete data and non-laboratory-confirmed t

SUBMITTER: Baruch J 

PROVIDER: S-EPMC9530510 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature