Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.

ABSTRACT:

Background

Human metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in children.

Methods

NPICS is an ongoing prospective study of children in Managua, Nicaragua. We assessed children for hMPV infection via real-time reverse-transcription polymerase chain reaction (RT-PCR). We used classical additive decomposition analysis to assess the temporal trends, and generalized growth models (GGMs) were used to estimate effective reproduction numbers.

Results

From 2011 to 2016, there were 564 hMPV symptomatic infections, yielding an incidence rate of 5.74 cases per 100 person-years (95% CI 5.3, 6.2). Children exper

SUBMITTER: Hacker K 

PROVIDER: S-EPMC9530515 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature