Muscle strength, but not body mass index, is associated with mortality in patients with non-alcoholic fatty liver disease.

ABSTRACT:

Background

Whether adiposity and muscle function are associated with mortality risk in patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. We examine the independent and combined associations of body mass index (BMI) and muscle strength with overall mortality in individuals with NAFLD.

Methods

We analysed data from 7083 participants with NAFLD in the Thai National Health Examination Survey and their linked mortality. NAFLD was defined using a lipid accumulation product in participants without significant alcohol intake. Poor muscle strength was defined by handgrip strength of <28 kg for men and <18 kg for women, according to the Asian Working Group on Sarcopenia. The Cox proportional-hazards model was constructed to estimate the adjusted hazard ratio (aH

SUBMITTER: Charatcharoenwitthaya P 

PROVIDER: S-EPMC9530524 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature