Predictors of response to acetylcholinesterase inhibitors in dementia: A systematic review.

ABSTRACT:

Background

The mainstay of therapy for many neurodegenerative dementias still relies on acetylcholinesterase inhibitors (AChEI); however, there is debate on various aspects of such treatment. A huge body of literature exists on possible predictors of response, but a comprehensive review is lacking. Therefore, our aim is to perform a systematic review of the predictors of response to AChEI in neurodegenerative dementias, providing a categorization and interpretation of the results.

Methods

We conducted a systematic review of the literature up to December 31^st, 2021, searching five different databases and registers, including studies on rivastigmine, donepezil, and galantamine, with clearly defined criteria for the diagnosis of dementia and the response to AChEI the

SUBMITTER: Pozzi FE 

PROVIDER: S-EPMC9530658 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature