Loss of Vhl alters trabecular bone loss during S. aureus osteomyelitis in a cell-specific manner.

ABSTRACT: Osteomyelitis, or bone infection, is a major complication of accidental trauma or surgical procedures involving the musculoskeletal system. Staphylococcus aureus is the most frequently isolated pathogen in osteomyelitis and triggers significant bone loss. Hypoxia-inducible factor (HIF) signaling has been implicated in antibacterial immune responses as well as bone development and repair. In this study, the impact of bone cell HIF signaling on antibacterial responses and pathologic changes in bone architecture was explored using genetic models with knockout of either Hif1a or a negative regulator of HIF-1α, Vhl. Deletion of Hif1a in osteoblast-lineage cells via Osx-Cre (Hif1a^ΔOB ) had no impact on bacterial clearance or pathologic changes

SUBMITTER: Ford CA 

PROVIDER: S-EPMC9530664 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature