Mammographic breast density and the risk of breast cancer: A systematic review and meta-analysis.

ABSTRACT:

Objectives

Mammographic density is a well-defined risk factor for breast cancer and having extremely dense breast tissue is associated with a one-to six-fold increased risk of breast cancer. However, it is questioned whether this increased risk estimate is applicable to current breast density classification methods. Therefore, the aim of this study was to further investigate and clarify the association between mammographic density and breast cancer risk based on current literature.

Methods

Medline, Embase and Web of Science were systematically searched for articles published since 2013, that used BI-RADS lexicon 5th edition and incorporated data on digital mammography. Crude and maximally confounder-adjusted data were pooled in odds ratios (ORs) using random-effects models.

SUBMITTER: Bodewes FTH 

PROVIDER: S-EPMC9530665 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature