Evaluation of the antinociceptive effects of a selection of triazine derivatives in mice.

ABSTRACT:

Background

The authors showed in a previous study that some novel triazine derivatives had an anti-inflammatory effect. The present study was designed to evaluate the antinociceptive effect of five out of nine compounds including two vanillin-triazine (5c and 5d) and three phenylpyrazole-triazine (10a, 10b, 10e) derivatives which showed the best anti-inflammatory effect.

Methods

Male Swiss mice (25-30 g) were used. To assess the antinociceptive effect, acetic acid-writhing, formalin, and hot plate tests were used after intraperitoneal injection of each compound.

Results

All compounds significantly (P < 0.001) reduced acetic acid-induced writhing at tested doses (50, 100, and 200 mg/kg). Also, the percent inhibition of writhing in the acetic acid test showed tha

SUBMITTER: Hajhashemi V 

PROVIDER: S-EPMC9530681 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature