Development of a high-throughput tailored imaging method in zebrafish to understand and treat neuromuscular diseases

ABSTRACT: The zebrafish (Danio rerio) is a vertebrate species offering multitude of advantages for the study of conserved biological systems in human and has considerably enriched our knowledge in developmental biology and physiology. Being equally important in medical research, the zebrafish has become a critical tool in the fields of diagnosis, gene discovery, disease modeling, and pharmacology-based therapy. Studies on the zebrafish neuromuscular system allowed for deciphering key molecular pathways in this tissue, and established it as a model of choice to study numerous motor neurons, neuromuscular junctions, and muscle diseases. Starting with the similarities of the zebrafish neuromuscular system with the human system, we review disease models associated with the neuromuscular system to focus

SUBMITTER: Lescouzeres L 

PROVIDER: S-EPMC9530744 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature