Key biomarkers and latent pathways of dysferlinopathy: Bioinformatics analysis and in vivo validation.

ABSTRACT:

Background

Dysferlinopathy refers to a group of muscle diseases with progressive muscle weakness and atrophy caused by pathogenic mutations of the DYSF gene. The pathogenesis remains unknown, and currently no specific treatment is available to alter the disease progression. This research aims to investigate important biomarkers and their latent biological pathways participating in dysferlinopathy and reveal the association with immune cell infiltration.

Methods

GSE3307 and GSE109178 were obtained from the Gene Expression Omnibus (GEO) database. Based on weighted gene co-expression network analysis (WGCNA) and differential expression analysis, coupled with least absolute shrinkage and selection operator (LASSO), the key genes for dysferlinopathy were identified. Functi

SUBMITTER: Xie Y 

PROVIDER: S-EPMC9530905 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature