The relationship between processed meat, red meat, and risk of types of cancer: A Mendelian randomization study

ABSTRACT:

Background

Observational studies have suggested processed and red meat may increase the risk of cancer. However, the causal effects and direction between them were still unclear. We conducted two-sample Mendelian randomization (MR) analysis to evaluate the causal effect of processed meat and red meat on the risk of nine common types of cancer, namely, lung, ovarian, endometrial, breast, kidney, gastric, prostate, skin, and oropharyngeal cancer.

Methods

Genome-wide association studies (GWAS) for processed meat and red meat (pork, beef, and mutton) were obtained from the UK Biobank. GWAS of types of cancer in this study were extracted from the genetic consortia and the FinnGen consortium. The inverse variance weighted (IVW) was carried out as the main method for two-sample

SUBMITTER: Wu K 

PROVIDER: S-EPMC9530935 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature