Langerhans Cell Histiocytosis: A Population-based Study of Anatomical Distribution and Treatment Patterns

ABSTRACT: Graphical abstract Highlights • LCH in bone marrow and lymph node are more likely to have multi-system involvement compared to LHC in other sites.• Craniofacial osseous LCH is more likely to be treated with surgery, vertebral LCH is less likely to be treated with surgery.• A racial disparity in surgery utilization is identified in pediatric patients with bone LCH.

Background

Langerhans cell histiocytosis (LCH) is a rare monoclonal histiocytic neoplasm. Little is known about clinical factors associated with LCH single- vs multi-system involvement at the time of diagnosis.

Methods

Data on 1549 LCH patients diagnosed between years 2010 and 2018 were extracted from the Surveillance, Epidemiology and End Results Program. Patterns of single- vs multisystem involvement were exa

SUBMITTER: Hu X 

PROVIDER: S-EPMC9530953 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature