Characterization of <i>POR</i> haplotype distribution in African populations and comparison with other global populations.

ABSTRACT: Background & aim: POR is an enzyme that mediates electron transfer to enable the drug-metabolizing activity of CYP450 proteins. However, POR has been understudied in pharmacogenomics despite this vital role. This study aimed to characterize the genetic variation in POR across African populations and to compare the star allele (haplotype) distribution with that in other global populations. Materials & methods: POR star alleles were called from whole-genome sequencing data using the StellarPGx pipeline. Results: In addition to the common POR*1 and *28 (defined by rs1057868), five novel rare haplotypes were computationally inferred. No significant frequency differences were observed among the majority of African populations. However,

SUBMITTER: Booyse RP 

PROVIDER: S-EPMC9531186 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature