Epitranscriptome profiling of spleen mRNA m⁶A methylation reveals pathways of host responses to malaria parasite infection.

ABSTRACT: N⁶ -Methyladenosine (m⁶A), the most abundant mammalian mRNA modification, has been reported to modulate various viral infections. Although it has been confirmed that RNA modifications can also modulate the replication and development of different parasites, the role of the RNA epitranscriptome in the regulation of host response post parasite infection remains to be elucidated. Here we report host spleen m⁶A epitranscriptome landscapes induced by different strains of the malaria parasite Plasmodium yoelii. We found that malaria parasite infection dramatically changes host spleen m⁶A mRNA modification and gene expression. Additionally, malaria parasite infection reprograms host immune response pathways by regulating the m⁶A

SUBMITTER: Wang L 

PROVIDER: S-EPMC9531237 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature