Suppression of Ca²⁺ signaling enhances melanoma progression.

ABSTRACT: The role of store-operated Ca²⁺ entry (SOCE) in melanoma metastasis is highly controversial. To address this, we here examined UV-dependent metastasis, revealing a critical role for SOCE suppression in melanoma progression. UV-induced cholesterol biosynthesis was critical for UV-induced SOCE suppression and subsequent metastasis, although SOCE suppression alone was both necessary and sufficient for metastasis to occur. Further, SOCE suppression was responsible for UV-dependent differences in gene expression associated with both increased invasion and reduced glucose metabolism. Functional analyses further established that increased glucose uptake leads to a metabolic shift towards biosynthetic pathways critical for melanoma metastasis. Finally, examination of fresh surgically is

SUBMITTER: Gross S 

PROVIDER: S-EPMC9531303 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature