PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
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ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC9531314 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
Chen Xu X Calandrelli Riccardo R Girardini John J Yan Zhangming Z Tan Zhiqun Z Xu Xiangmin X Hiniker Annie A Zhong Sheng S
Cell metabolism 20220501 5
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology. ...[more]
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