H3K18 lactylation marks tissue-specific active enhancers.

ABSTRACT:

Background

Histone lactylation has been recently described as a novel histone post-translational modification linking cellular metabolism to epigenetic regulation.

Results

Given the expected relevance of this modification and current limited knowledge of its function, we generate genome-wide datasets of H3K18la distribution in various in vitro and in vivo samples, including mouse embryonic stem cells, macrophages, adipocytes, and mouse and human skeletal muscle. We compare them to profiles of well-established histone modifications and gene expression patterns. Supervised and unsupervised bioinformatics analysis shows that global H3K18la distribution resembles H3K27ac, although we also find notable differences. H3K18la marks active CpG island-containing promoters of highly ex

SUBMITTER: Galle E 

PROVIDER: S-EPMC9531456 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature