Identification of CPT2 as a prognostic biomarker by integrating the metabolism-associated gene signature in colorectal cancer.

ABSTRACT:

Background

The incidence of colorectal cancer (CRC) is considered to be the third-highest malignant tumor among all carcinomas. The alterations in cellular bioenergetics (metabolic reprogramming) are associated with several malignant phenotypes in CRC, such as tumor cell proliferation, invasion, metastasis, chemotherapy resistance, as well as promotes its immune escape. However, the expression pattern of metabolism-associated genes that mediate metabolic reprogramming in CRC remains unknown.

Methods

In this study, we screened out CPT2 by investigating the function of a series of metabolism-related genes in CRC progression by integrating the data from the TCGA and GEO databases. Next, we collected CRC tissues (n = 24) and adjacent non-tumor tissues (n = 8) and analyzed mRNA l

SUBMITTER: Liu J 

PROVIDER: S-EPMC9531485 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature