Evidence of transgenerational effects on autism spectrum disorder using multigenerational space-time cluster detection.

ABSTRACT: Transgenerational epigenetic risks associated with complex health outcomes, such as autism spectrum disorder (ASD), have attracted increasing attention. Transgenerational environmental risk exposures with potential for epigenetic effects can be effectively identified using space-time clustering. Specifically applied to ancestors of individuals with disease outcomes, space-time clustering characterized for vulnerable developmental stages of growth can provide a measure of relative risk for disease outcomes in descendants. (1) Identify space-time clusters of ancestors with a descendent with a clinical ASD diagnosis and matched controls. (2) Identify developmental windows of ancestors with the highest relative risk for ASD in descendants. (3) Identify how the relative risk may vary through th

SUBMITTER: Richards Steed R 

PROVIDER: S-EPMC9531495 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature