Kruppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.

ABSTRACT:

Background

Ribosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere translational machineries, ribosomes might play an active role in tumor initiation and progression. Despite its importance, regulation of ribosomal biogenesis is still not completely understood.

Methods

Using Gene Set Enrichment Analysis of RNA sequencing and proteomical mass spectrometry data in breast cancer cells expressing Krüppel-like factor 7 (KLF7), we identified processes altered by this transcription factor. In silico analyses of a cohort of breast cancer patients in The Cancer Genome Atlas confirmed our finding. We further verified the role of KLF7 the identified ribosomal processes in in vitro assays of mammary carc

SUBMITTER: Luchtenborg AM 

PROVIDER: S-EPMC9531505 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature