Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy.

ABSTRACT:

Background

Cortical atrophy is associated with cognitive decline, but the association is not perfect. We aimed to identify factors explaining the discrepancy between the degree of cortical atrophy and cognitive decline in cognitively unimpaired elderly.

Methods

The discrepancy between atrophy and cognitive decline was measured using the residuals from a linear regression analysis between change in whole brain cortical thickness over time and change in a cognitive composite measure over time in 395 cognitively unimpaired participants from the Swedish BioFINDER study. We tested for bivariate associations of this residual measure with demographic, imaging, and fluid biomarker variables using Pearson correlations and independent-samples t-tests, and for multivariate associations

SUBMITTER: Svenningsson AL 

PROVIDER: S-EPMC9531524 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature