Assessing sex-based differences in postsurgical clinical outcomes after use of del Nido cardioplegia.

ABSTRACT:

Objectives

del Nido cardioplegia is used to pharmacologically arrest the heart during cardiac surgery and decrease reperfusion- and ischaemia-related myocardial injury. Studies have demonstrated the physiological differences between male and female hearts, potentially related to cardiac size or myocyte calcium handling; we aimed to assess for between-sex differences in clinical outcomes after receipt of del Nido cardioplegia.

Methods

Patients who underwent coronary artery bypass or coronary artery bypass graft/valve surgery at our institution using del Nido cardioplegia (January 2014 to December 2019) were included (n = 2118). Clinical data were collected retrospectively. After the creation of a propensity-matched cohort (n = 1252), multivariable logistic regression was used

SUBMITTER: Honzel E 

PROVIDER: S-EPMC9531685 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature