Associations between peripheral inflammatory markers and amygdala activity and connectivity in response to emotional faces in adolescents.

ABSTRACT: Research in adults suggests that higher peripheral inflammation is associated with increased threat-related amygdala activity and reduced cortico-amygdala connectivity. However, there is limited research in adolescents, which is striking given the major developmental changes that occur in cortico-amygdala circuitry during adolescence. In this study, we examine the association between peripheral inflammation and amygdala activity and connectivity to emotional faces in a community sample of adolescents. Participants included 88 adolescents 12 to 15 years old who provided a blood sample and underwent fMRI scanning while completing a face and shape matching task that included fearful, angry, and happy faces. Blood samples were assayed for interleukin-6 (IL-6), C-reactive protein (CRP), and tum

SUBMITTER: Swartz JR 

PROVIDER: S-EPMC9531728 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature