Phylodynamics of a regional SARS-CoV-2 rapid spreading event in Colorado in late 2020.

ABSTRACT: Since the initial reported discovery of SARS-CoV-2 in late 2019, genomic surveillance has been an important tool to understand its transmission and evolution. Here, we sought to describe the underlying regional phylodynamics before and during a rapid spreading event that was documented by surveillance protocols of the United States Air Force Academy (USAFA) in late October-November of 2020. We used replicate long-read sequencing on Colorado SARS-CoV-2 genomes collected July through November 2020 at the University of Colorado Anschutz Medical campus in Aurora and the United States Air Force Academy in Colorado Springs. Replicate sequencing allowed rigorous validation of variation and placement in a phylogenetic relatedness network. We focus on describing the phylodynamics of a lineage that

SUBMITTER: Wade KJ 

PROVIDER: S-EPMC9531818 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature