Tear proteome profile in eyes with keratoconus after intracorneal ring segment implantation or corneal crosslinking.

ABSTRACT:

Purpose

Keratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and Intracorneal Ring Segment (ICRS) are widely used treatments in KC disease, but the alterations they cause in biomechanical mediators are still poorly understood. The aim of this study was to analyze the tear proteome profile before and after treatments to identify biomarkers altered by surgery.

Materials and methods

An observational, prospective, case-control pilot study was conducted, analyzing tear samples from KC patients by nano-liquid chromatography-mass spectrometry (nLC-MS/MS). Data are available via ProteomeX

SUBMITTER: Goni N 

PROVIDER: S-EPMC9531826 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature