The inconsistent mediating effect of catechol O methyl transferase Val¹⁵⁸Met polymorphism on the sex difference of cognitive impairment in schizophrenia patients.

ABSTRACT:

Objective

Schizophrenia is a multifaceted mental disorder characterized by heterogeneous positive/negative symptoms and cognitive deficits. Sex differences have been reported in various aspects of the disease. However, the underlying genetic reasons remain unelucidated. Recent studies show that the influence of COMT Val158Met (rs4680) variation is sexually dimorphic. Thus, this study aims to explore whether there is an effect of the interaction between COMT Val158Met (rs4680) polymorphism and sex on patients' clinical characteristics and cognitive function.

Materials and methods

We recruited 367 in patients with chronic schizophrenia (246 males and 121 females) and 419 healthy controls (172 males and 247 females). The cognitive performance was assessed by Repea

SUBMITTER: Xu H 

PROVIDER: S-EPMC9531860 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature