Pharmacology, Toxicology, and Rational Application of Cinnabar, Realgar, and Their Formulations

ABSTRACT:

Materials and Methods

A search was performed for the literature on cinnabar and realgar in PubMed, the Chinese Pharmacopeia, Google, and other sources. The search included studies using single herbs, traditional formulations, or novel dosage forms.

Results

Cinnabar and cinnabar formulas exhibit good efficacy for sedation, sleep improvement, anxiety alleviation, and brain protection. However, previous studies on neurotransmitters have reached different conclusions, and detailed pharmacological mechanisms are lacking. Realgar and its formulas exert promising antitumor activity through regulation of cell cycle arrest, intrinsic and extrinsic apoptosis, induction of differentiation, autophagy, metabolic reprogramming, matrix metalloproteinase-9 (MMP-9) signaling, and reacti

SUBMITTER: Guan H 

PROVIDER: S-EPMC9532072 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature