Treatment outcome and prognostic analysis of advanced large cell neuroendocrine carcinoma of the lung.

ABSTRACT: The optimal systemic treatment of advanced large cell neuroendocrine carcinoma (LCNEC) is still controversial. We intend to explore advanced LCNEC through SEER database, construct nomogram model of advanced LCNEC, and understand the effect of different treatment regimens on LCNEC. We collected 909 patients, divided them into a training set validation set, constructed nomograms using Cox proportional hazards regression models, and evaluated nomogram discrimination and calibration by C-index and calibration curves. Kaplan-Meier will also be used to compare OS in different groups of patients and to explore the impact of different treatment regimens on advanced LCNEC. On the nomogram plotted, the nomogram predicted AUC values over time were always greater than 0.7, the C-index was 0.681 (95% C

SUBMITTER: Xia L 

PROVIDER: S-EPMC9532410 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature