Development of a potential PET probe for HDAC6 imaging in Alzheimer's disease.

ABSTRACT: Although the epigenetic regulatory protein histone deacetylase 6 (HDAC6) has been recently implicated in the etiology of Alzheimer's disease (AD), little is known about the role of HDAC6 in the etiopathogenesis of AD and whether HDAC6 can be a potential therapeutic target for AD. Here, we performed positron emission tomography (PET) imaging in combination with histopathological analysis to better understand the underlying pathomechanisms of HDAC6 in AD. We first developed [¹⁸F]PB118 which was demonstrated as a valid HDAC6 radioligand with excellent brain penetration and high specificity to HDAC6. PET studies of [¹⁸F]PB118 in 5xFAD mice showed significantly increased radioactivity in the brain compared to WT animals, with more pronounced changes identified in the corte

SUBMITTER: Bai P 

PROVIDER: S-EPMC9532562 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature