5-Methylcytosine (m⁵C) modification in peripheral blood immune cells is a novel non-invasive biomarker for colorectal cancer diagnosis.

ABSTRACT: Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading to poor prognosis. Dysregulation of 5-Methylcytosine (m⁵C) RNA has gradually been reported in various cancers, but their role in tumor diagnosis is rarely mentioned. Our study aimed to determine the role of m⁵C methylation modification in blood immune cells for the diagnosis of CRC. Peripheral blood samples were obtained from a total of 83 healthy controls and 196 CRC patients. We observed that m⁵C RNA contents in blood immune cells of CRC patients were markedly enhanced in both training set and validation set. Moreover, levels of m⁵C increased with CRC progression and metastasis but reduced after trea

SUBMITTER: Yin H 

PROVIDER: S-EPMC9532581 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature