Gallbladder microbiota in early vertebrates provides evolutionary insights into mucosal homeostasis.

ABSTRACT: The gallbladder (GB) microbiota plays critical roles in mammalian metabolism and immune homeostasis, and its relationship with human disease has been extensively studied over the past decade. However, very little is known about the interplay between GB microbiota and the immune functions of teleost fish, the earliest bony vertebrate with a GB. Therefore, this study sought to investigate the composition of the teleost GB microbiota and the potential mechanisms through which it affects mucosal immunity. In our results, we found that the GB mucosa (GM) and bile bacterial community shared a similar microbiological composition with that of the gut mucosa in naïve individuals. IHNV infection induced a profound GB inflammation and disrupted their microbial homeostasis followed by a strong anti-ba

SUBMITTER: Ding LG 

PROVIDER: S-EPMC9532620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature