Dataset Information

Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its in vitro digestion profile.

ABSTRACT: The use of antioxidant-loaded protein-polysaccharide nanoparticle in stabilizing and delivering curcumin with high internal phase Pickering emulsions is comparatively scarce. Resveratrol (RES)-loaded α-lactalbumin (ALA)-chitosan (CHI) particles were fabricated and used for curcumin-loaded high internal phase Pickering emulsions (HIPPEs) stabilization and delivery. CLSM illustrated that RES-ALA-CHI nanoparticles were effectively adsorbed on oil/water (O/W) interface and a gel-like structure was formed surrounding oil droplets. All HIPPEs exhibited excellent physical stability. CUR retention was 75.4 % for HIPPEs with RES-ALA-CHI colloidal particles, which was appreciably higher than that with ALA-CHI colloidal particles (63.9 %) after 30 days storage. Compared to bulk medium-chain triglyceride (MCT), both lipolysis extent and curcumin (CUR) bioaccessibility were pronouncedly enhanced with HIPPEs-based delivery systems. But both HIPPEs (51.4 % and 43.7 %) exhibited lower extent of lipolysis than conventional emulsions (90.4 %). The occurrence of RES significantly restrained the lipolysis. These results demonstrated that HIPPEs could be excellent delivery systems for delivering lipophilic curcumin.

SUBMITTER: Fan Y

PROVIDER: S-EPMC9532759 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its <i>in vitro</i> digestion profile.

Fan Yuting Y Luo Dixue D Yi Jiang J

Food chemistry: X 20220818

The use of antioxidant-loaded protein-polysaccharide nanoparticle in stabilizing and delivering curcumin with high internal phase Pickering emulsions is comparatively scarce. Resveratrol (RES)-loaded α-lactalbumin (ALA)-chitosan (CHI) particles were fabricated and used for curcumin-loaded high internal phase Pickering emulsions (HIPPEs) stabilization and delivery. CLSM illustrated that RES-ALA-CHI nanoparticles were effectively adsorbed on oil/water (O/W) interface and a gel-like structure was f ...[more]

PMID: 36211747

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Project description:Periodontitis (PD) as a chronic inflammatory disease instigated by periodontal pathogenic bacteria and mediated by the host immune response, resulting in the destruction of supporting periodontal tissue and tooth loss in adults. Constructing an injectable delivery system that allows for sustained drug release within periodontal pockets to continuously eliminate pathogenic bacteria, reduce periodontal inflammation, and promote periodontal tissue regeneration is an effective strategy for periodontitis treatment. Here, we explore the therapeutic potential and underlying mechanisms of curcumin-loaded Pickering emulsion (PE-CUR) in periodontitis treatment. The Pickering emulsion formulation offers an effective delivery system, enhancing curcumin's bioavailability and therapeutic efficacy. In vitro studies, we demonstrate that the PE-CUR exhibit excellent biocompatibility and anti-inflammatory property by elimination of reactive oxygen species (ROS). In addition, PE-CUR significantly eliminate key periodontal pathogens, including Porphyromonas gingivalis (P. gingivalis) and Staphylococcus aureus (S. aureus). In a rat model of periodontitis, PE-CUR significantly attenuates periodontal tissue inflammation and alveolar bone loss, indicating a protective effect against periodontal tissue destruction. Mechanistically, PE-CUR promotes the expression of anti-inflammatory factors and inhibits the release of pro-inflammatory factors by regulating macrophage polarization from M1 to M2 and modulating the MAPK and PI3K-AKT signaling pathway. Furthermore, PE-CUR decreases the formation of osteoclasts as well as stimulates the activation and differentiation of osteoblasts successively, thereby ameliorating the periodontal inflammation and promoting the alveolar bone regeneration. Overall, our findings elucidate the therapeutic mechanisms of PE-CUR in periodontitis, suggesting its potential as a promising treatment strategy warranting further clinical investigation.

Dataset Information

Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its in vitro digestion profile.

Publications

Resveratrol-loaded α-lactalbumin-chitosan nanoparticle-encapsulated high internal phase Pickering emulsion for curcumin protection and its <i>in vitro</i> digestion profile.

Similar Datasets

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