Effect of chemotherapy on the uterus of young adult cancer survivors.

ABSTRACT:

Objective

To investigate the impact of chemotherapy on the uterus.

Design

Cross-sectional pilot study.

Setting

Single university fertility clinic.

Patients

Twelve patients with a history of alkylating agent chemotherapy exposure after Hodgkin lymphoma (cancer) vs. 12 normally menstruating women (controls).

Interventions

The inclusion criteria were age of 18-45 years and consent for endometrial biopsy. The exclusion criteria were the absence of the uterus, completed pelvic radiation, uterine or cervical cancer, and metastatic cancer. Each participant underwent endometrial biopsy and pelvic ultrasound. All study visits were conducted in the late proliferative phase of the menstrual cycle.

Main outcome measures

Uterine volume, blood flow, endometrial

SUBMITTER: Garg D 

PROVIDER: S-EPMC9532891 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature