Efficacy and safety of 3-n-butylphthalide for the treatment of cognitive impairment: A systematic review and meta-analysis.

ABSTRACT:

Background

Current evidence for the efficacy of pharmacological treatment in improving cognitive function is absent. Recent studies have reported that 3-n-butylphthalide (NBP) has a positive effect on improving cognitive impairment; however, its clinical efficacy and safety is unclear. Therefore, we conducted a meta-analysis to assess its efficacy and safety for cognitive impairment.

Methods

We systematically searched the PubMed, EMBASE, Cochrane Library, Web of Science, and Scopus databases, and two reviewers independently screened and extracted the data from included studies. We synthesized the data using the Review Manager Software version 5.3.

Results

We included six randomized clinical trials (RCTs), encompassing 851 patients with cognitive impairment. The result

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9532910 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature