Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease.

ABSTRACT: Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBD) resulting from the interaction of multiple environmental, genetic and immunological factors. CD5 and CD6 are paralogs encoding lymphocyte co-receptors involved in fine-tuning intracellular signals delivered upon antigen-specific recognition, microbial pattern recognition and cell adhesion. While CD5 and CD6 expression and variation is known to influence some immune-mediated inflammatory disorders, their role in IBD remains unclear. To this end, Cd5- and Cd6-deficient mice were subjected to dextran sulfate sodium (DSS)-induced colitis, the most widely used experimental animal model of IBD. The two mouse lines showed opposite results regarding body weight loss and

SUBMITTER: Casado-Llombart S 

PROVIDER: S-EPMC9532939 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature