Signature of gene expression profile of liver sinusoidal endothelial cells in nonalcoholic steatohepatitis.

ABSTRACT: Background: There has been emerging evidence that liver sinusoidal endothelial cells (LSECs) play an important role in the pathogenesis of nonalcoholic steatohepatitis (NASH). This study aims to figure out the signature of the gene expression profile of LSECs in NASH and to explore potential biomarkers related to damaged LSECs in NASH. Methods and materials: Animal experiments were performed to demonstrate the significant structural damage of LSECs in the NASH model. To further understand the functional changes of these damaged LSECs in NASH, we used the public GEO database that contained microarray data for the gene expression of LSECs in NASH and normal mouse liver. Differentially expressed genes (DEGs) were analyzed, and further Gene Ontology (GO) enrichment analysis was p

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9533023 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature