An interdisciplinary approach to characterize peanut-allergic patients-First data from the FOOD@ consortium.

ABSTRACT:

Background

Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls.

Methods

Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data.

Results

We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylat

SUBMITTER: Worm M 

PROVIDER: S-EPMC9533219 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature