Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis.

ABSTRACT:

Background

Treatments for nonalcoholic steatohepatitis (NASH) are urgently needed. Hepatic fat fraction and shear stiffness quantified by magnetic resonance imaging (MRI-HFF) and magnetic resonance elastography (MRE-SS), respectively, are biomarkers for hepatic steatosis and fibrosis.

Purpose

This study assessed the longitudinal effects of fibroblast growth factor 21 variant (polyethylene glycol [PEG]-FGF21v) on MRI-HFF and MRE-SS in a NASH mouse model.

Study type

Preclinical.

Animal model

This study included a choline-deficient, amino acid-defined, high-fat diet (CDAHFD) model and 6-week-old, male C57BL/6J mice (N = 78).

Field strength/sequence

This study was performed using: 3T: gradient-echo two-point Dixon and spin-echo (SE) echo-planar imaging elast

SUBMITTER: Tang H 

PROVIDER: S-EPMC9533307 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature