Glucocorticoids and Rates of Biphasic Reactions in Patients with Adrenaline-Treated Anaphylaxis: A Propensity Score Matching Analysis.

ABSTRACT:

Background

The effectiveness of glucocorticoids in preventing biphasic reactions in patients with anaphylaxis remains controversial.

Objective

We evaluated the effects of glucocorticoids on rates of biphasic reactions in hospitalized patients with anaphylaxis treated with adrenaline.

Methods

In this retrospective observational study using a national inpatient database in Japan, we identified 31,570 hospitalized patients with anaphylaxis treated with adrenaline on the day of admission. We divided them into two groups: those who were treated with adrenaline plus glucocorticoids and those who received adrenaline only on the day of admission. The primary outcome was the occurrence of a biphasic reaction, defined as requiring two or more ampules of adrenaline within 7 days

SUBMITTER: Nagata S 

PROVIDER: S-EPMC9533429 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature