Prolactin Reduces Hippocampal Parvalbumin and GABAA Receptor Expression in Female Mice.

ABSTRACT:

Introduction

Parvalbumin (PV)-positive cells are strategic elements of neuronal networks capable of influencing memory and learning processes. However, it is not known whether pituitary hormones may be related to PV expression in the hippocampus - a part of the limbic system with important functions in learning and memory.

Objective

Since previous studies indicate that prolactin (PRL) plays a significant role in hippocampal-dependent learning and synaptic plasticity, we hypothesized that a rise in PRL levels can modify PV expression in the hippocampus.

Methods

We employed biochemical, immunohistochemistry, and densitometry techniques - as well as a behavioural assay - in a hyperprolactinemia model using subcutaneous osmotic pumps in female mice.

Results

PRL tre

SUBMITTER: Mellado S 

PROVIDER: S-EPMC9533442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature