Interaction of miR-200a-3p with YAP regulates cell proliferation and metastasis differentially in HPV-positive and HPV-negative cervical cancer cells.

ABSTRACT:

Background

Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with different HPV statuses remains unknown. The present study was to investigate the differential effects of either miR-200a-3p or YAP on tumorous cells' fate in vitro in HPV-negative and HPV-positive cervical cancer cell models, and to explore if the changes in proliferation, migration, and invasion of the CC cells with different HPV statuses could be attributed to the differential interactions between miR-200a-3p and YAP.

Methods

The colony formation assays, EDU assays and Transwell assays were performed for CC cell proliferation, migration and invasion capacities ana

SUBMITTER: Chen H 

PROVIDER: S-EPMC9533500 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature