Cytogenetic profile of adult acute myeloid leukemia in Egypt: a single-center experience.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a diverse disease characterized by the expansion of blasts of myeloid lineage. Cytogenetic testing is the cornerstone for risk stratification of AML patients. Geographical and environmental factors may play a very important role in the development of leukemia and several differences in genetic profile may be seen among different ethnicities. In our study, we evaluated cytogenetic findings of adult AML patients in South Egypt.

Methods

Cytogenetic testing (karyotyping and M-FISH) was performed for 120 adult patients with AML. Twenty metaphases were analyzed for each patient.

Results

In our study, the median age of AML patients was 36.5 years, with an age range between 18 and 86 years. 56.7% of patients had normal karyotypes and

SUBMITTER: Elnaggar MG 

PROVIDER: S-EPMC9533520 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature