Cancer-associated fibroblast-derived gene signatures predict radiotherapeutic survival in prostate cancer patients.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs) play multiple roles in regulating tumor metastasis and treatment response. Current clinical indicators are insufficient to accurately assess disease risk and radiotherapy response, emphasizing the urgent need for additional molecular prognostic markers.

Methods

In order to investigate CAF-related genes associated with radiotherapy and construct prognostic CAF-related gene signatures for prostate cancer, we firstly established a radio-resistant prostate CAF cell subline (referred to as CAFR) from Mus-CAF (referred to as CAF) through fractionated irradiation using X-rays. Transcriptome sequencing for CAF and CAFR was conducted, and 2626 CAF-related differentially expressed genes (DEGs) associated with radiotherapy were identified

SUBMITTER: Zhang R 

PROVIDER: S-EPMC9533530 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature