Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study.

ABSTRACT:

Background

Epidemiological evidence relating obesity to peptic ulcer disease (PUD) has been mixed. Here we sought to determine the causality in the association of obesity with PUD risk using the Mendelian randomization (MR) approach.

Methods

This study was based on summary-level data for body mass index (BMI), waist-to-hip ratio (WHR), and PUD derived from large genome-wide association studies (GWASs). Single nucleotide polymorphisms significantly associated with BMI and WHR (P < 5 × 10^-8) were leveraged as instrumental variables. Causal estimates were pooled using several meta-analysis methods. In addition, multivariable MR was employed to account for covariation between BMI and WHR, as well as to explore potential mediators.

Results

Genetically predicted

SUBMITTER: Li Z 

PROVIDER: S-EPMC9533532 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature