SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity.

ABSTRACT:

Background

Multiple sclerosis (MS) is a chronic, debilitating condition characterized by CNS autoimmunity stemming from a complex etiology involving both environmental and genetic factors. Our current understanding of MS points to dysregulation of the immune system as the pathogenic culprit, however, it remains unknown as to how the many genes associated with increased susceptibility to MS are involved. One such gene linked to MS susceptibility and known to regulate immune function is the self-ligand immune cell receptor SLAMF7.

Methods

We subjected WT and SLAMF7^-/- mice to multiple EAE models, compared disease severity, and comprehensively profiled the CNS immune landscape of these mice. We identified all SLAMF7-expressing CNS immune cells and compared the entire

SUBMITTER: O'Connell P 

PROVIDER: S-EPMC9533612 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature