Metabolomic profiling of bovine leucocytes transformed by Theileria annulata under BW720c treatment.

ABSTRACT:

Background

When Theileria annulata infects host cells, it undertakes unlimited proliferation as tumor cells. Although the transformed cells will recover their limited reproductive characteristics and enter the apoptosis process after treatment with buparvaquone (BW720c), the metabolites and metabolic pathways involved are not clear.

Methods

The transformed cells of T. annulata were used as experimental materials, and the buparvaquone treatment group and DMSO control group were used. Qualitative and quantitative analysis was undertaken of 36 cell samples based on the LC-QTOF platform in positive and negative ion modes. The metabolites of the cell samples after 72 h of drug treatment were analyzed, as were the different metabolites and metabolic pathways involved in the BW720c

SUBMITTER: Zhao HX 

PROVIDER: S-EPMC9533618 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature