BLNIMDA: identifying miRNA-disease associations based on weighted bi-level network.

ABSTRACT:

Background

MicroRNAs (miRNAs) have been confirmed to be inextricably linked to the emergence of human complex diseases. The identification of the disease-related miRNAs has gradually become a routine way to unveil the genetic mechanisms of examined disorders.

Methods

In this study, a method BLNIMDA based on a weighted bi-level network was proposed for predicting hidden associations between miRNAs and diseases. For this purpose, the known associations between miRNAs and diseases as well as integrated similarities between miRNAs and diseases are mapped into a bi-level network. Based on the developed bi-level network, the miRNA-disease associations (MDAs) are defined as strong associations, potential associations and no associations. Then, each miRNA-disease pair (MDP) is assig

SUBMITTER: Shang J 

PROVIDER: S-EPMC9533620 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature